Researchers discover compound that speeds up diabetic wound healing

November 26, 2015

Notre Dame researchers discover compound that speeds up diabetic wound healing


Non-healing chronic wounds are a major complication of diabetes, which result in more than 70,000 lower-limb amputations in the United States alone each year. The reasons why diabetic wounds are resistant to healing are not fully understood, and there are limited therapeutic agents that could accelerate or facilitate their repair. University of Notre Dame researchers have discovered a compound that accelerates diabetic wound healing, which may open the door to new treatment strategies. A team of researchers from Notre Dame’s Department of Chemistry and Biochemistry, led by Mayland Chang, previously identified two enzymes called matrix metalloproteinases (MMPs), MMP-8 and MMP-9, in the wounds of diabetic mice. They proposed that the former might play a role in the body’s response to wound healing and the latter was the pathological consequence of the disease with detrimental effects. The researchers used the MMP-9 inhibitor referred to as ND-322, which accelerated wound healing in diabetic mice.

In a new study that appears in the journal Proceedings of the National Academy of Sciences (PNAS), the researchers report the discovery of a better MMP-9 inhibitor referred to as ND-336. “ND-336 is a six-fold more pote

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October 23, 2015

Gift vouchers can now be purchased from our clinic. Vouchers make the perfect gift idea, especially for those people you care about who may need that extra motivation to see a podiatrist. Regular patients are also perfect recipients of a voucher, or you could even buy one for yourself! To find out more, please contact us via telephone on 9523 2053 or at the clinic (223 Hawthorn Rd, Caulfield North).

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October 12, 2015

Read the first of two articles in a series about running and the possible injuries that can be sustained from this fun, healthy but potentially hazardous sport.  

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September 22, 2015
(BPT) – A growing number of desk-bound office workers are choosing to stand at their workstations, hoping to reap the health benefits associated with working while upright. Yet millions of Americans, such as nurses, waitresses, factory workers and more, don’t have a choice about standing on their feet all day. For many of them, working on their feet has the potential to negatively impact their bodies, their mental well-being and even their productivity, reveals a new survey conducted by Futuro Graduated Compression Legwear from 3M. The survey found that standing workers said they felt less productive. And those who are on their feet for more than four hours a day also felt the effects in their personal lives, having skipped exercise, foregone socializing with friends, skipped playtime with their kids and let household chores slide due to leg and foot discomfort. If you’re among the millions of Americans who have to work on their feet, here are some tips to help relieve discomfort related to standing for long periods of time: * Wear the right shoes. If you’re on your feet all day, avoiding dress shoes and high heels may be obvious, but you still may not be wearing the best shoe for your needs. Choose shoes made for people who stand a lot. The

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